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Remote asymmetric induction

Smith, Alan Arthur (1990) Remote asymmetric induction. Doctor of Philosophy (PhD) thesis, University of Kent. (doi:10.22024/UniKent/01.02.94662) (KAR id:94662)


The synthesis and characterization of substrates suitable for the study of [1,3]-, [1,4]- and [l,5]-asymmetric induction was undertaken. Their reduction in the presence of Lewis acids was investigated. The extent and direction of asymmetric induction was investigated by variation of Lewis acid, solvent and reducing agent. Competing mechanisms in [1,5]-symmetric reductions was demonstrated. Molecular mechanics calculations were used to predict the extent and direction of asymmetric induction on the basis of the lower energy conformers of suitable model structures. Crystal structures were used to develop a set of MM2 force field parameters for an octahedral titanium complex. An ab initio study was prepared in order to improve the parameterization of the MM2 force field.

Item Type: Thesis (Doctor of Philosophy (PhD))
DOI/Identification number: 10.22024/UniKent/01.02.94662
Additional information: This thesis has been digitised by EThOS, the British Library digitisation service, for purposes of preservation and dissemination. It was uploaded to KAR on 25 April 2022 in order to hold its content and record within University of Kent systems. It is available Open Access using a Creative Commons Attribution, Non-commercial, No Derivatives ( licence so that the thesis and its author, can benefit from opportunities for increased readership and citation. This was done in line with University of Kent policies ( If you feel that your rights are compromised by open access to this thesis, or if you would like more information about its availability, please contact us at and we will seriously consider your claim under the terms of our Take-Down Policy (
Uncontrolled keywords: Organic chemistry
Subjects: Q Science > QD Chemistry
Divisions: Divisions > Division of Natural Sciences > Chemistry and Forensics
SWORD Depositor: SWORD Copy
Depositing User: SWORD Copy
Date Deposited: 13 Jul 2023 11:19 UTC
Last Modified: 14 Jul 2023 13:58 UTC
Resource URI: (The current URI for this page, for reference purposes)

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