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The application of low coherence interferometry to the micron scale imaging of the living human retina

Dobre, George (2000) The application of low coherence interferometry to the micron scale imaging of the living human retina. Doctor of Philosophy (PhD) thesis, University of Kent. (doi:10.22024/UniKent/01.02.94311) (KAR id:94311)

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Current optical and ultrasound techniques for high resolution in vivo retinal imaging cannot provide the depth accuracy required to enable sensitive ophthalmologic diagnosis to be carried out on the basis of images of retinal microstructures. The axial depth resolution of one of the recently introduced retinal imaging instruments, the scanning laser ophthalmoscope, is restricted by the combined effect of the depth of focus achievable through the eye pupil and aberrations to about 300 pm. A new imaging technique, based on low coherence interferometry, providing improved depth resolution figures of the order of a few microns, is demonstrated here. Non-invasive topographic and tomographic measurements can be performed with an instrument based on this technique. A novel path modulation procedure, the Newton rings sampling function, is presented together with experimental results obtained in its application to the imaging of various objects including human in vivo retina. The advantages and disadvantages of novel and more conventional imaging modes, their associated techniques and the overall importance and likely impact of the novel Newton rings modulation method are considered. The measurement of 3-dimensional profiles of various targets, including tomographic images of in vivo human retinas from volunteers’ eyes, is presented. The utility of OCT measurements in the high-resolution mapping of in vivo tissue and its potential usage alongside scanning laser ophthalmoscopy in identifying features in the human eye are discussed.

Item Type: Thesis (Doctor of Philosophy (PhD))
Thesis advisor: Jackson, David A.
DOI/Identification number: 10.22024/UniKent/01.02.94311
Additional information: This thesis has been digitised by EThOS, the British Library digitisation service, for purposes of preservation and dissemination. It was uploaded to KAR on 25 April 2022 in order to hold its content and record within University of Kent systems. It is available Open Access using a Creative Commons Attribution, Non-commercial, No Derivatives ( licence so that the thesis and its author, can benefit from opportunities for increased readership and citation. This was done in line with University of Kent policies ( If you feel that your rights are compromised by open access to this thesis, or if you would like more information about its availability, please contact us at and we will seriously consider your claim under the terms of our Take-Down Policy (
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Physics and Astronomy
SWORD Depositor: SWORD Copy
Depositing User: SWORD Copy
Date Deposited: 27 Oct 2022 14:48 UTC
Last Modified: 27 Oct 2022 14:49 UTC
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