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Endocytosis at the Crossroad of Polarity and Signaling Regulation: Learning from Drosophila melanogaster and Beyond

Papagiannouli, Fani (2022) Endocytosis at the Crossroad of Polarity and Signaling Regulation: Learning from Drosophila melanogaster and Beyond. International Journal of Molecular Sciences, 23 (9). Article Number 4684. ISSN 1422-0067. (doi:10.3390/ijms23094684) (KAR id:94132)

Abstract

Cellular trafficking through the endosomal–lysosomal system is essential for the transport of cargo proteins, receptors and lipids from the plasma membrane inside the cells and across membranous organelles. By acting as sorting stations, vesicle compartments direct the fate of their content for degradation, recycling to the membrane or transport to the trans-Golgi network. To effectively communicate with their neighbors, cells need to regulate their compartmentation and guide their signaling machineries to cortical membranes underlying these contact sites. Endosomal trafficking is indispensable for the polarized distribution of fate determinants, adaptors and junctional proteins. Conversely, endocytic machineries cooperate with polarity and scaffolding components to internalize receptors and target them to discrete membrane domains. Depending on the cell and tissue context, receptor endocytosis can terminate signaling responses but can also activate them within endosomes that act as signaling platforms. Therefore, cell homeostasis and responses to environmental cues rely on the dynamic cooperation of endosomal–lysosomal machineries with polarity and signaling cues. This review aims to address advances and emerging concepts on the cooperative regulation of endocytosis, polarity and signaling, primarily in Drosophila melanogaster and discuss some of the open questions across the different cell and tissue types that have not yet been fully explored.

Item Type: Article
DOI/Identification number: 10.3390/ijms23094684
Uncontrolled keywords: cell trafficking; endocytosis; lysosome; signaling regulation; polarity; Dlg; Scrib; Lgl; EGFR; Notch; Drosophila testis; squamous epithelia; intestine; autophagy; PAR complex; JNK; Rab proteins; nephrocytes; SOP; Saccharomyces cerevisiae; Arrestins; mTOR; TORC1
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Fani Papagiannouli
Date Deposited: 24 Apr 2022 12:30 UTC
Last Modified: 25 Apr 2022 09:45 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/94132 (The current URI for this page, for reference purposes)

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