Skip to main content
Kent Academic Repository

A computational framework for canonical holistic morphometric analysis of trabecular bone

Bachman, Sebastian, Dunmore, Christopher J., Skinner, Matthew M., Pahr, Dieter H., Synek, Alexander (2022) A computational framework for canonical holistic morphometric analysis of trabecular bone. Scientific Reports, 12 . Article Number 5187. E-ISSN 2045-2322. (doi:10.1038/s41598-022-09063-6) (KAR id:93840)


Bone is a remarkable, living tissue that functionally adapts to external loading. Therefore, bone shape and internal structure carry information relevant to many disciplines, including medicine, forensic science, and anthropology. However, morphometric comparisons of homologous regions across different individuals or groups are still challenging. In this study, two methods were combined to quantify such differences: (1) Holistic morphometric analysis (HMA) was used to quantify morphometric values in each bone, (2) which could then be mapped to a volumetric mesh of a canonical bone created by a statistical free-form deformation model (SDM). Required parameters for

this canonical holistic morphometric analysis (cHMA) method were identified and the robustness of the method was evaluated. The robustness studies showed that the SDM converged after one to two iterations, had only a marginal bias towards the chosen starting image, and could handle large shape differences seen in bones of different species. Case studies were performed on metacarpal bones and proximal femora of different primate species to confirm prior study results. The differences between species could be visualised and statistically analysed in both case studies. cHMA provides a framework for performing quantitative comparisons of different morphometric quantities across individuals or groups. These comparisons facilitate investigation of the relationship between spatial morphometric variations and function or pathology, or both.

Item Type: Article
DOI/Identification number: 10.1038/s41598-022-09063-6
Uncontrolled keywords: trabecular bone, morphometric analysis
Subjects: Q Science > QH Natural history > QH324.2 Computational biology
Q Science > QM Human anatomy
Divisions: Divisions > Division of Human and Social Sciences > School of Anthropology and Conservation
Depositing User: Chris Dunmore
Date Deposited: 04 Apr 2022 10:20 UTC
Last Modified: 05 Apr 2022 09:59 UTC
Resource URI: (The current URI for this page, for reference purposes)

University of Kent Author Information

Dunmore, Christopher J..

Creator's ORCID:
CReDIT Contributor Roles:

Skinner, Matthew M..

Creator's ORCID:
CReDIT Contributor Roles:
  • Depositors only (login required):

Total unique views for this document in KAR since July 2020. For more details click on the image.