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Isolation of infectious Lloviu virus from Schreiber’s bats in Hungary

Kemenesi, Gábor, Tóth, Gábor E., Mayora-Neto, Martin, Scott, Simon D., Temperton, Nigel J., Wright, Edward, Mühlberger, Elke, Hume, Adam J., Suder, Ellen L., Zana, Brigitta, and others. (2022) Isolation of infectious Lloviu virus from Schreiber’s bats in Hungary. Nature Communications, 13 (1). Article Number 1706. ISSN 2041-1723. (doi:10.1038/s41467-022-29298-1) (KAR id:93792)

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https://doi.org/10.1038/s41467-022-29298-1

Abstract

Some filoviruses can be transmitted to humans by zoonotic spillover events from their natural host and filovirus outbreaks have occured with increasing frequency in the last years. The filovirus Lloviu virus (LLOV), was identified in 2002 in Schreiber’s bats (Miniopterus schreibersii) in Spain and was subsequently detected in bats in Hungary. Here we isolate infectious LLOV from the blood of a live sampled Schreiber’s bat in Hungary. The isolate is subsequently sequenced and cultured in the Miniopterus sp. kidney cell line SuBK12-08. It is furthermore able to infect monkey and human cells, suggesting that LLOV might have spillover potential. A multi-year surveillance of LLOV in bats in Hungary detects LLOV RNA in both deceased and live animals as well as in coupled ectoparasites from the families Nycteribiidae and Ixodidae. This correlates with LLOV seropositivity in sampled Schreiber’s bats. Our data support the role of bats, specifically Miniopterus schreibersii as hosts for LLOV in Europe. We suggest that bat-associated parasites might play a role in the natural ecology of filoviruses in temperate climate regions compared to filoviruses in the tropics.

Item Type: Article
DOI/Identification number: 10.1038/s41467-022-29298-1
Uncontrolled keywords: Pathogens, Viral reservoirs, Virus–host interactions
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Nigel Temperton
Date Deposited: 31 Mar 2022 12:38 UTC
Last Modified: 01 Apr 2022 11:59 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/93792 (The current URI for this page, for reference purposes)
Scott, Simon D.: https://orcid.org/0000-0002-8290-0461
Temperton, Nigel J.: https://orcid.org/0000-0002-7978-3815
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