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Mammalian comparative genomics reveals epigenetic features associated with genome reshuffling in rodentia

Capilla, Laia, Sanchez-Guillen, Rosa A, Farré, Marta, Paytuvi-Gallart, Andreu, Maliverni, Roberto, Ventura, Jacint, Larkin, Denis M., Ruiz-Herrera, Aurora (2016) Mammalian comparative genomics reveals epigenetic features associated with genome reshuffling in rodentia. Genome Biology and Evolution, . pp. 3703-3717. ISSN 1759-6653. (doi:10.1093/gbe/evw276) (KAR id:92114)

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Official URL
https://doi.org/10.1093/gbe/evw276

Abstract

Understanding how mammalian genomes have been reshuffled through structural changes is fundamental to the dynamics of its composition, evolutionary relationships between species and, in the long run, speciation. In this work, we reveal the evolutionary genomic landscape in Rodentia, the most diverse and speciose mammalian order, by whole-genome comparisons of six rodent species and six representative outgroup mammalian species. The reconstruction of the evolutionary breakpoint regions across rodent phylogeny shows an increased rate of genome reshuffling that is approximately two orders of magnitude greater than in other mammalian species here considered. We identified novel lineage and clade-specific breakpoint regions within Rodentia and analyzed their gene content, recombination rates and their relationship with constitutive lamina genomic associated domains, DNase I hypersensitivity sites and chromatin modifications. We detected an accumulation of protein-coding genes in evolutionary breakpoint regions, especially genes implicated in reproduction and pheromone detection and mating. Moreover, we found an association of the evolutionary breakpoint regions with active chromatin state landscapes, most probably related to gene enrichment. Our results have two important implications for understanding the mechanisms that govern and constrain mammalian genome evolution. The first is that the presence of genes related to species-specific phenotypes in evolutionary breakpoint regions reinforces the adaptive value of genome reshuffling. Second, that chromatin conformation, an aspect that has been often overlooked in comparative genomic studies, might play a role in modeling the genomic distribution of evolutionary breakpoints.

Item Type: Article
DOI/Identification number: 10.1093/gbe/evw276
Uncontrolled keywords: rodents, evolutionary breakpoints, recombination, lamina associated domains, KRAB genes, epigenome
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Marta Farre Belmonte
Date Deposited: 05 Dec 2021 21:30 UTC
Last Modified: 09 Dec 2021 12:09 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/92114 (The current URI for this page, for reference purposes)
Farré, Marta: https://orcid.org/0000-0001-9170-5767
Larkin, Denis M.: https://orcid.org/0000-0001-7859-6201
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