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Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants

Reynolds, Catherine J., Gibbons, Joseph M., Pade, Corinna, Lin, Kai-Min, Sandoval, Diana Munoz, Pieper, Franziska, Butler, David K., Liu, Siyi, Otter, Ashley, Joy, George, and others. (2021) Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants. Science, . ISSN 0036-8075. (doi:10.1126/science.abm0811) (KAR id:91986)


The impact of initial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infecting strain on downstream immunity to heterologous variants of concern (VOC) is unknown. Studying a longitudinal healthcare worker cohort, we found that after three antigen exposures (infection+two vaccine doses), S1 antibody, memory B cells and heterologous neutralization of B.1.351, P.1 and B.1.617.2 plateaued, while B.1.1.7 neutralization and spike T cell responses increased. Serology using Wuhan Hu-1 spike receptor binding domain poorly predicted neutralizing immunity against VOCs. Neutralization potency against VOCs changed with heterologous virus encounter and number of antigen exposures. Neutralization potency fell differentially depending on targeted VOCs over 5-months from the second vaccine dose. Heterologous combinations of spike encountered during infection and vaccination shape subsequent cross-protection against VOC, with implications for future-proof next-generation vaccines.

Item Type: Article
DOI/Identification number: 10.1126/science.abm0811
Additional information: I am a member of the COVIDsortium Investigators. The full list of authors belonging to the COVIDsortium are listed in the Supplementary material of the paper.
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Nigel Temperton
Date Deposited: 03 Dec 2021 13:52 UTC
Last Modified: 06 Dec 2021 09:27 UTC
Resource URI: (The current URI for this page, for reference purposes)

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