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The Human Mucosal Mycobiome and Fungal Community Interactions

Witherden, Elizabeth A., Shoaie, Saeed, Hall, Rebecca A., Moyes, David L. (2017) The Human Mucosal Mycobiome and Fungal Community Interactions. Journal of Fungi, 3 (4). p. 56. ISSN 2309-608X. (doi:10.3390/jof3040056) (KAR id:91839)

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Official URL:
https://doi.org/10.3390/jof3040056

Abstract

With the advent of high-throughput sequencing techniques, the astonishing extent and complexity of the microbial communities that reside within and upon us has begun to become clear. Moreover, with advances in computing and modelling methods, we are now beginning to grasp just how dynamic our interactions with these communities are. The diversity of both these communities and their interactions—both within the community and with us—are dependent on a multitude of factors, both microbial- and host-mediated. Importantly, it is becoming clear that shifts in the makeup of these communities, or their responses, are linked to different disease states. Although much of the work to define these interactions and links has been investigating bacterial communities, recently there has been significant growth in the body of knowledge, indicating that shifts in the host fungal communities (mycobiome) are also intimately linked to disease status. In this review, we will explore these associations, along with the interactions between fungal communities and their human and microbial habitat, and discuss the future applications of systems biology in determining their role in disease status.

Item Type: Article
DOI/Identification number: 10.3390/jof3040056
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Becky Hall
Date Deposited: 01 Dec 2021 08:52 UTC
Last Modified: 02 Dec 2021 22:52 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/91839 (The current URI for this page, for reference purposes)
Hall, Rebecca A.: https://orcid.org/0000-0002-4908-8168
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