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Dynamic Fungal Cell Wall Architecture in Stress Adaptation and Immune Evasion

Hopke, Alex, Brown, Alistair J.P., Hall, Rebecca A., Wheeler, Robert T. (2018) Dynamic Fungal Cell Wall Architecture in Stress Adaptation and Immune Evasion. Trends in Microbiology, 26 (4). pp. 284-295. ISSN 0966-842X. (doi:10.1016/j.tim.2018.01.007) (KAR id:91792)


Deadly infections from opportunistic fungi have risen in frequency, largely because of the at-risk immunocompromised population created by advances in modern medicine and the HIV/AIDS pandemic. This review focuses on dynamics of the fungal polysaccharide cell wall, which plays an outsized role in fungal pathogenesis and therapy because it acts as both an environmental barrier and as the major interface with the host immune system. Human fungal pathogens use architectural strategies to mask epitopes from the host and prevent immune surveillance, and recent work elucidates how biotic and abiotic stresses present during infection can either block or enhance masking. The signaling components implicated in regulating fungal immune recognition can teach us how cell wall dynamics are controlled, and represent potential targets for interventions designed to boost or dampen immunity.

Item Type: Article
DOI/Identification number: 10.1016/j.tim.2018.01.007
Subjects: Q Science > QR Microbiology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Becky Hall
Date Deposited: 30 Nov 2021 12:20 UTC
Last Modified: 01 Dec 2021 13:40 UTC
Resource URI: (The current URI for this page, for reference purposes)

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