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Noisy neighbourhoods: quorum sensing in fungal-polymicrobial infections

Dixon, Emily F., Hall, Rebecca A. (2015) Noisy neighbourhoods: quorum sensing in fungal-polymicrobial infections. Cellular Microbiology, 17 (10). pp. 1431-1441. ISSN 1462-5814. (doi:10.1111/cmi.12490) (KAR id:91786)

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Quorum sensing was once considered a way in which a species was able to sense its cell density and regulate gene expression accordingly. However, it is now becoming apparent that multiple microbes can sense particular quorum-sensing molecules, enabling them to sense and respond to other microbes in their neighbourhood. Such interactions are significant within the context of polymicrobial disease, in which the competition or cooperation of microbes can alter disease progression. Fungi comprise a small but important component of the human microbiome and are in constant contact with bacteria and viruses. The discovery of quorum-sensing pathways in fungi has led to the characterization of a number of interkingdom quorum-sensing interactions. Here, we review the recent developments in quorum sensing in medically important fungi, and the implications these interactions have on the host's innate immune response.

Item Type: Article
DOI/Identification number: 10.1111/cmi.12490
Subjects: Q Science > QR Microbiology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Becky Hall
Date Deposited: 30 Nov 2021 11:41 UTC
Last Modified: 01 Dec 2021 13:56 UTC
Resource URI: (The current URI for this page, for reference purposes)
Hall, Rebecca A.:
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