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On and Off: Epigenetic Regulation of C. albicans Morphological Switches

Iracane, E, Vega-Estévez, Samuel, Buscaino, Alessia (2021) On and Off: Epigenetic Regulation of C. albicans Morphological Switches. Pathogens, . Article Number 1463. ISSN 2076-0817. (doi:10.3390/pathogens10111463) (KAR id:91687)

Abstract

The human fungal pathogen Candida albicans is a dimorphic opportunistic pathogen that colonises most of the human population without creating any harm. However, this fungus can also cause life-threatening infections in immunocompromised individuals. The ability to successfully colonise different host niches is critical for establishing infections and pathogenesis. C. albicans can live and divide in various morphological forms critical for its survival in the host. Indeed, C. albicans can grow as both yeast and hyphae and can form biofilms containing hyphae. The transcriptional regulatory network governing the switching between these different forms is complex but well understood. In contrast, non-DNA based epigenetic modulation is emerging as a crucial but still poorly studied regulatory mechanism of morphological transition. This review explores our current understanding of chromatin-mediated epigenetic regulation of the yeast to hyphae switch and biofilm formation. We highlight how modification of chromatin structure and non-coding RNAs contribute to these morphological transitions.

Item Type: Article
DOI/Identification number: 10.3390/pathogens10111463
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Alessia Buscaino
Date Deposited: 22 Nov 2021 15:54 UTC
Last Modified: 23 Nov 2021 11:50 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/91687 (The current URI for this page, for reference purposes)

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