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Molecular mechanisms of incretin hormone secretion

Ezcurra, Marina, Reimann, Frank, Gribble, Fiona M, Emery, Edward (2013) Molecular mechanisms of incretin hormone secretion. Current Opinion in Pharmacology, 13 (6). pp. 922-927. ISSN 1471-4892. (doi:10.1016/j.coph.2013.08.013) (KAR id:91125)

Abstract

Incretin peptides (glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)) are secreted from enteroendocrine cells in the intestinal epithelium, and help to coordinate metabolic responses to food ingestion. A number of molecular mechanisms have recently been defined that underlie carbohydrate, lipid and protein sensing in gut endocrine cells. Knockout mice lacking sodium glucose tranporter-1 (SGLT-1) or the short chain fatty acid sensing receptor FFAR2 (GPR43), for example, have highlighted the importance of these molecules in incretin secretion. This review outlines our current understanding of sensory pathways in incretin secreting cells and highlights the therapeutic potential of targeting them for the development of novel therapies for obesity and diabetes.

Item Type: Article
DOI/Identification number: 10.1016/j.coph.2013.08.013
Subjects: Q Science > QP Physiology (Living systems)
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Marina Ezcurra
Date Deposited: 27 Oct 2021 16:18 UTC
Last Modified: 16 Nov 2021 10:27 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/91125 (The current URI for this page, for reference purposes)

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