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Neuropeptidergic Signaling and Active Feeding State Inhibit Nociception in Caenorhabditis elegans

Ezcurra, Marina, Walker, Denise S., Beets, Isabel, Swoboda, Peter, Schafer, W. (2016) Neuropeptidergic Signaling and Active Feeding State Inhibit Nociception in Caenorhabditis elegans. Journal of Neuroscience, 36 (11). pp. 3157-3169. ISSN 0270-6474. (doi:10.1523/JNEUROSCI.1128-15.2016) (KAR id:91108)


Food availability and nutritional status are important cues affecting behavioral states. Here we report that, in Caenorhabditis elegans, a cascade of dopamine and neuropeptide signaling acts to inhibit nociception in food-poor environments. In the absence of food, animals show decreased sensitivity and increased adaptation to soluble repellents sensed by the polymodal ASH nociceptors. The effects of food on adaptation are affected by dopamine and neuropeptide signaling; dopamine acts via the DOP-1 receptor to decrease adaptation on food, whereas the neuropeptide receptors NPR-1 and NPR-2 act to increase adaptation off food. NPR-1 and NPR-2 function cell autonomously in the ASH neurons to increase adaptation off food, whereas the DOP-1 receptor controls neuropeptide release from interneurons that modulate ASH activity indirectly. These results indicate that feeding state modulates nociception through the interaction of monoamine and neuropeptide signaling pathways.

Item Type: Article
DOI/Identification number: 10.1523/JNEUROSCI.1128-15.2016
Uncontrolled keywords: C. elegans, chemosensation, dopamine, neuromodulation, neuropeptide
Subjects: Q Science > QP Physiology (Living systems)
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Marina Ezcurra
Date Deposited: 27 Oct 2021 08:29 UTC
Last Modified: 10 Dec 2022 04:04 UTC
Resource URI: (The current URI for this page, for reference purposes)

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