Skip to main content

The phospholipid membrane compositions of bacterial cells, cancer cell lines and biological samples from cancer patients

Hilton, Kira L.F., Manwani, Chandni, Boles, Jessica E., White, Lisa J., Ozturk, Sena, Garrett, Michelle D., Hiscock, Jennifer R. (2021) The phospholipid membrane compositions of bacterial cells, cancer cell lines and biological samples from cancer patients. Chemical Science, 12 . pp. 13273-13282. ISSN 2041-6520. (doi:10.1039/D1SC03597E) (KAR id:90289)

PDF Publisher pdf
Language: English


Download (462kB) Preview
[thumbnail of d1sc03597e.pdf]
Preview
This file may not be suitable for users of assistive technology.
Request an accessible format
Official URL
http://dx.doi.org/10.1039/D1SC03597E

Abstract

While cancer now impacts the health and well-being of more of the human population than ever before, the exponential rise in antimicrobial resistant (AMR) bacterial infections means AMR is predicted to become one of the greatest future threats to human health. It is therefore vital that novel therapeutic strategies are developed that can be used in the treatment of both cancer and AMR infections. Whether the target of a therapeutic agent be inside the cell or in the cell membrane, it must either interact with or cross this phospholipid barrier to elicit the desired cellular effect. Here we summarise findings from published research into the phospholipid membrane composition of bacterial and cancer cell lines and biological samples from cancer patients. These data not only highlight key differences in the membrane composition of these biological samples, but also the methods used to elucidate and report the results of this analogous research between the microbial and cancer fields.

Item Type: Article
DOI/Identification number: 10.1039/D1SC03597E
Subjects: Q Science
Q Science > Q Science (General)
Divisions: Divisions > Division of Natural Sciences > Chemistry and Forensics
Depositing User: Jennifer Hiscock
Date Deposited: 21 Sep 2021 13:10 UTC
Last Modified: 26 Nov 2021 16:58 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/90289 (The current URI for this page, for reference purposes)
Garrett, Michelle D.: https://orcid.org/0000-0002-3939-1673
Hiscock, Jennifer R.: https://orcid.org/0000-0002-1406-8802
  • Depositors only (login required):