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Comprehensive framework for human health risk assessment of nanopesticides

Kah, Melanie, Johnston, Linda J., Kookana, Rai S., Bruce, Wendy, Haase, Andrea, Ritz, Vera, Dinglasan, Jordan, Doak, Shareen, Garelick, Hemda, Gubala, Vladimir and others. (2021) Comprehensive framework for human health risk assessment of nanopesticides. Nature nanotechnology, 16 . pp. 955-964. ISSN 1748-3387. E-ISSN 1748-3395. (doi:10.1038/s41565-021-00964-7) (KAR id:90228)


Nanopesticides are not only in an advanced state of research and development but have started to appear on the market. Industry and regulatory agencies need a consolidated and comprehensive framework and guidance for human health risk assessments. In this perspective we develop such a comprehensive framework by exploring two case studies from relevant product types: an active ingredient delivered with a nanocarrier system, and a nanoparticle as an active ingredient. For a nanocarrier system, three entities are tracked during the assessment: the nanocarrier–active ingredient complex, the empty nanocarrier remaining after the complete release of the active ingredient, and the released active ingredient. For the nanoparticle of pure active ingredient, only two entities are relevant: the nanoparticle and the released ions. We suggest important adaptations of the existing pesticide framework to determine the relevant nanopesticide entities and their concentrations for toxicity testing. Depending on the nature of the nanopesticides, additional data requirements, such as those pertaining to durability in biological media and potential for crossing biological barriers, have also been identified. Overall, our framework suggests a tiered approach for human health risk assessment, which is applicable for a range of nanopesticide products to support regulators and industry in making informed decisions on nanopesticide submissions. Brief summaries of suitable methods including references to existing standards (if available) have been included together with an analysis of current knowledge gaps. Our study is an important step towards a harmonized approach accepted by regulatory agencies for assessing nanopesticides.

Item Type: Article
DOI/Identification number: 10.1038/s41565-021-00964-7
Uncontrolled keywords: nano-pesticides, risk assessment, human health, nano-toxicology
Subjects: Q Science > QD Chemistry
S Agriculture > S Agriculture (General)
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Vladimir Gubala
Date Deposited: 15 Sep 2021 09:41 UTC
Last Modified: 13 Mar 2022 00:00 UTC
Resource URI: (The current URI for this page, for reference purposes)

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