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Atomic-Scale Structural Characterization of Silver-Doped Phosphate-Based Glasses Prepared by Coacervation

Kyffin, B. A., Pickup, D. M., Mountjoy, G., Foroutan, F., Abrahams, I., Carta, D. (2021) Atomic-Scale Structural Characterization of Silver-Doped Phosphate-Based Glasses Prepared by Coacervation. The Journal of Physical Chemistry C, 125 (22). pp. 12256-12268. ISSN 1932-7447. (doi:10.1021/acs.jpcc.1c00363) (KAR id:89846)


Phosphate-based glasses (PBGs) are traditionally prepared using the high temperature melt quenching route (MQ) or via the more recent sol-gel method (SG) that requires the use of organic solvents. The coacervation method represents an excellent inexpensive and green alternative to MQ and SG, being performed in aqueous solution and at room temperature. Coacervation is particularly applicable for the production of PBGs designed for biomedical applications, because it allows for the inclusion of temperature sensitive molecules and it does not require the use of toxic solvents. Whereas the atomic structure of the melt quenched and sol-gel PBGs is known, the atomic structure of those prepared via coacervation has yet to be investigated.

In this study, a comprehensive advanced structural characterization has been performed on phosphate-based glasses in the system P2O5–CaO–Na2O–Ag2O (Ag2O mol% = 0, 1, 3, 5, 9 and 14) prepared via the coacervation method. Glasses within this system should find application as bioresorbable biomaterials thanks to their ability to release bioactive ions in a controlled manner. In particular, they possess antibacterial properties, inferred by the release of Ag+ over time.

High energy X-ray diffraction (HEXRD), 31P and 23Na solid state magic angle spinning nuclear magnetic resonance (MAS NMR) and X-ray Absorption (XAS) at the Ag K-edge were used to probe the atomic structure of the glasses after drying in vacuum and after calcination at 300 °C.

The length of the polyphosphate chains in the solid state appears to be independent of silver concentration, however, significant degradation of these chains is seen after calcination at 300 °C. Atomic-scale structure results indicate that the structure of these glasses is akin to that of other silver doped phosphate glasses prepared using the MQ and SG method. This suggests that phosphate-based glasses prepared using milder and greener conditions may have similar chemical and physical properties such as solubility, biocompatibility, and antibacterial properties.

Item Type: Article
DOI/Identification number: 10.1021/acs.jpcc.1c00363
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Physics and Astronomy
Depositing User: Gavin Mountjoy
Date Deposited: 19 Aug 2021 14:14 UTC
Last Modified: 14 Jan 2022 15:58 UTC
Resource URI: (The current URI for this page, for reference purposes)

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Pickup, D. M..

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Mountjoy, G..

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