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Effect of nonionic and amphoteric surfactants on salivary pellicles reconstituted in vitro

Barker, Robert, Gonzalez‐Martinez, Juan, Welbourn, Rebecca J.L., Ma, Kun, Li, Peixun, Gutfreund, Philipp, Klechikov, Alexey, Arnebrant, Thomas, Sotres, Javier (2021) Effect of nonionic and amphoteric surfactants on salivary pellicles reconstituted in vitro. Scientific Reports, . Article Number 12913. ISSN 2045-2322. (doi:10.1038/s41598-021-92505-4) (KAR id:89638)

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http://dx.doi.org/10.1038/s41598-021-92505-4

Abstract

Surfactants are important components of oral care products. Sodium dodecyl sulfate (SDS) is the most common because of its foaming properties, taste and low cost. However, the use of ionic surfactants, especially SDS, is related to several oral mucosa conditions. Thus, there is a high interest in using non‐ ionic and amphoteric surfactants as they are less irritant. To better understand the performance of these surfactants in oral care products, we investigated their interaction with salivary pellicles i.e., the proteinaceous films that cover surfaces exposed to saliva. Specifically, we focused on pentaethylene glycol monododecyl ether (C12E5) and cocamidopropyl betaine (CAPB) as model nonionic and amphoteric surfactants respectively, and investigated their interaction with reconstituted salivary pellicles with various surface techniques: Quartz Crystal Microbalance with Dissipation, Ellipsometry, Force Spectroscopy and Neutron Reflectometry. Both C12E5 and CAPB were gentler on pellicles than SDS, removing a lower amount. However, their interaction with pellicles differed. Our work indicates that CAPB would mainly interact with the mucin components of pellicles, leading to collapse and dehydration. In contrast, exposure to C12E5 had a minimal effect on the pellicles, mainly resulting in the replacement/solubilisation of some of the components anchoring pellicles to their substrate.

Item Type: Article
DOI/Identification number: 10.1038/s41598-021-92505-4
Subjects: Q Science > QC Physics > QC176.8.N35 Nanoscience, nanotechnology
Q Science > QD Chemistry > QD431 Organic Chemistry- Biochemistry- Proteins, peptides, amino acids
Q Science > QD Chemistry > QD473 Physical properties in relation to structure
Q Science > QD Chemistry > Analytical Chemistry
Q Science > QP Physiology (Living systems) > QP517 Biochemistry
Divisions: Divisions > Division of Natural Sciences > School of Physical Sciences
Signature Themes: Food Systems, Natural Resources and Environment, Future Human
Depositing User: Robert Barker
Date Deposited: 05 Aug 2021 11:57 UTC
Last Modified: 06 Aug 2021 14:23 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/89638 (The current URI for this page, for reference purposes)
Barker, Robert: https://orcid.org/0000-0002-8645-5385
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