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Ultrahigh nanostructured drug payloads from degradable mesoporous silicon aerocrystals

Nadarassan, D., Loni, A., Canham, L.T., Scoutaris, N., Trivedi, V., Douroumis, D. (2021) Ultrahigh nanostructured drug payloads from degradable mesoporous silicon aerocrystals. International Journal of Pharmaceutics, . Article Number 120840. ISSN 0378-5173. (doi:10.1016/j.ijpharm.2021.120840) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:89375)

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https://doi.org/10.1016/j.ijpharm.2021.120840

Abstract

Porous silicon has found increased attention as a drug delivery system due to its unique features such as high drug payloads, surface area and biodegradation. In this study supercritical fluid (SCF) assisted drying of ultrahigh porosity (> 90%) silicon particles and flakes was shown to result in much higher mesopore volumes (~ 4.66 cm3/g) and surface areas (~ 680 m2/g) than with air-drying. The loading and physical state of the model drug (S)-(+)-Ibuprofen in SCF dried matrices was quantified and assessed using thermogravimetric analysis, differential scanning calorimetry, UV-Vis spectrophotometry, gravimetric analysis, gas adsorption and electron microscopy. Internal drug payloads of up to 72% were achieved which was substantially higher than values published for both conventionally dried porous silicon (17-51%) and other mesoporous materials (7-45%). In-vitro degradability kinetics of SCF-dried matrices in simulated media was also found to be faster than air-dried controls. The in-vitro release studies provided improved but sustained drug dissolution at both pH 2.0 and pH 7.4.

Item Type: Article
DOI/Identification number: 10.1016/j.ijpharm.2021.120840
Uncontrolled keywords: Porous silicon, Ibuprofen, Supercritical fluid, Controlled release, degradable
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Signature Themes: Future Human, Food Systems, Natural Resources and Environment
Depositing User: Vivek Trivedi
Date Deposited: 20 Jul 2021 09:35 UTC
Last Modified: 26 Jul 2021 14:34 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/89375 (The current URI for this page, for reference purposes)
Trivedi, V.: https://orcid.org/0000-0001-9304-9214
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