Antibodies to factor XII and recurrent fetal loss in patients with the anti-phospholipid syndrome.

Jones, David Wynne and Mackie, Ian J. and Gallimore, Michael J. and Winter, Mark (2001) Antibodies to factor XII and recurrent fetal loss in patients with the anti-phospholipid syndrome. British Journal of Haematology, 113 . pp. 550-552. (Access to this publication is restricted)

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Abstract

Forty female patients with either primary anti-phospholipid syndrome (n = 26) or systemic lupus erythematosus (anti-phospholipid syndrome positive) (n = 14) were investigated for levels of factor XII, the presence of lupus anticoagulant and antibodies to cardiolipin, beta 2-glycoprotein I and factor XII. Twenty-one patients had a history of recurrent fetal loss (> 2, mean = 2.6). Lupus anticoagulant positivity showed a weak association with recurrent fetal loss (odds ratio = 1.1). While there was no association between the presence of antibodies to cardiolipin or beta 2-glycoprotein I with recurrent fetal loss, antibodies to factor XII showed a strong and statistically significant association (odds ratio = 5.4, P = 0.025).

Item Type:	Article
Subjects:	Q Science
Divisions:	Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
Depositing User:	Sue Davies
Date Deposited:	19 Dec 2007 17:56
Last Modified:	01 May 2014 13:57
Resource URI:	https://kar.kent.ac.uk/id/eprint/89 (The current URI for this page, for reference purposes)