En-Face Optical Coherence Tomography: A New Method to Analyse Structural Changes of the Optic Nerve Head in Rat Glaucoma

Guo, Lin and Tsatourian, V. and Luong, V. and Podoleanu, Adrian G.H. and Jackson, David A. and Fitzke, Fred W. and Cordeiro, M.F. (2005) En-Face Optical Coherence Tomography: A New Method to Analyse Structural Changes of the Optic Nerve Head in Rat Glaucoma. British Journal Opththalmology, 89 . pp. 1210-1216. ISSN 0007-1161 . (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Aim: To investigate en face optical coherence tomography ( eOCT) and its use as an effective objective technique for assessing changes in the glaucomatous rat optic nerve head ( ONH) in vivo, and compare it with confocal scanning laser ophthalmoscopy ( cSLO). Methods: 18 Dark Agouti ( DA) rats with surgically induced ocular hypertension were imaged with eOCT and cSLO at regular intervals. Assessment included three dimensional ( 3D) topographic reconstructions, intensity z- profile plots, a new method of depth analysis to define a " multilayered'' structure, and scleral canal measurements, in relation to the degree of intraocular pressure ( IOP) exposure. Results: The increased depth resolution of the eOCT compared to the cSLO was apparent in all methods of analysis, with better discrimination of tissue planes. This was validated histologically. eOCT demonstrated several significant changes in imaged rat ONH which correlated with IOP exposure, including the area of ONH ( p < 0.01), separation between retinal vessel and scleral layers ( p < 0.05), and anterior scleral canal opening expansion ( p < 0.05). Conclusion: eOCT appears to be effective in assessing rat ONH, allowing detailed structural analysis of the multilayered ONH structure. As far as the authors are aware, this is the first report of scleral canal expansion in a rat model. They suggest eOCT as a novel method for the detection of early changes in the ONH in glaucoma

Item Type: Article
Subjects: T Technology > TK Electrical engineering. Electronics Nuclear engineering > TK7800 Electronics (see also: telecommunications)
Divisions: Faculties > Science Technology and Medical Studies > School of Physical Sciences
Depositing User: Yiqing Liang
Date Deposited: 06 Sep 2008 09:05
Last Modified: 08 Jul 2014 08:17
Resource URI: https://kar.kent.ac.uk/id/eprint/8886 (The current URI for this page, for reference purposes)
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