Dora, Nova Olympia, Blackburn, Edith, Boles, Jessica E., Williams, George T., White, Lisa J., Turner, Scarlett, Hothersall, Trevor, Askwith, Trevor, Doolan, Jack, Mulvihill, Daniel P., and others. (2021) Supramolecular self-associating amphiphiles (SSAs) as nanoscale enhancers of cisplatin anticancer activity. RSC Advances, 11 . pp. 14213-14217. ISSN 2046-2069. (doi:10.1039/D1RA02281D) (KAR id:87520)
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Official URL: http://dx.doi.org/10.1039/D1RA02281D |
Abstract
Many chemotherapeutic drugs have a narrow therapeutic window due to inefficient tumour cell permeation.Supramolecular self-associating amphiphilic salts (SSAs) are a unique class of small molecules that offer potential as nextgeneration cancer drugs and/or therapeutic enhancement agents. Herein, we demonstrate the cytotoxicity of seven SSAstowards both ovarian and glioblastoma cancer cells. We also utilize the intrinsic fluorescent properties of one of these leadSSAs to provide evidence for this class of compound to both bind to the exterior cancer cell surface and permeate the cellmembrane, to become internalized. Furthermore, we demonstrate synergistic effects of two lead SSAs on cisplatin-mediatedcytotoxicity of ovarian cancer cells and show that this correlates with increased DNA damage and apoptosis versus eitheragent alone. This work provides the first evidence that SSAs interact with and permeate cancer cell membranes and enhancethe cytotoxic activity of a chemotherapeutic drug in human cancer cells.
Item Type: | Article |
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DOI/Identification number: | 10.1039/D1RA02281D |
Subjects: |
Q Science Q Science > QD Chemistry Q Science > QD Chemistry > QD431 Organic Chemistry- Biochemistry- Proteins, peptides, amino acids |
Divisions: | Divisions > Division of Natural Sciences > Physics and Astronomy |
Depositing User: | Jennifer Hiscock |
Date Deposited: | 09 Apr 2021 10:13 UTC |
Last Modified: | 04 Jul 2023 13:22 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/87520 (The current URI for this page, for reference purposes) |
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