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The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans

Esh, Christoper J., Chrismas, Bryna C R, Mauger, Alexis R., Cherif, A, Molphy, John, Taylor, Lee (2021) The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans. Scientific Reports, 11 . Article Number 6531. ISSN 2045-2322. (doi:10.1038/s41598-021-84563-5) (KAR id:87155)

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Abstract

Whether cyclooxygenase (COX)/prostaglandin E2 (PGE2) thermoregulatory pathways, observed in rodents, present in humans? Participants (n = 9) were exposed to three environments; cold (20 °C), thermoneutral (30 °C) and hot (40 °C) for 120 min. Core (Tc)/skin temperature and thermal perception were recorded every 15 min, with COX/PGE2 concentrations determined at baseline, 60 and 120 min. Linear mixed models identified differences between and within subjects/conditions. Random coefficient models determined relationships between Tc and COX/PGE2. Tc [mean (range)] increased in hot [+ 0.8 (0.4–1.2) °C; p < 0.0001; effect size (ES): 2.9], decreased in cold [− 0.5 (− 0.8 to − 0.2) °C; p < 0.0001; ES 2.6] and was unchanged in thermoneutral [+ 0.1 (− 0.2 to 0.4) °C; p = 0.3502]. A relationship between COX2/PGE2 in cold (p = 0.0012) and cold/thermoneutral [collapsed, condition and time (p = 0.0243)] was seen, with higher PGE2 associated with higher Tc. A within condition relationship between Tc/PGE2 was observed in thermoneutral (p = 0.0202) and cold/thermoneutral [collapsed, condition and time (p = 0.0079)] but not cold (p = 0.0631). The data suggests a thermogenic response of the COX/PGE2 pathway insufficient to defend Tc in cold. Further human in vivo research which manipulates COX/PGE2 bioavailability and participant acclimation/acclimatization are warranted to elucidate the influence of COX/PGE2 on Tc.

Item Type: Article
DOI/Identification number: 10.1038/s41598-021-84563-5
Uncontrolled keywords: Enzyme mechanisms, Homeostasis
Subjects: Q Science > QP Physiology (Living systems)
Divisions: Divisions > Division of Natural Sciences > School of Sport and Exercise Sciences
Signature Themes: Future Human
Depositing User: Lex Mauger
Date Deposited: 16 Mar 2021 12:58 UTC
Last Modified: 29 Jun 2021 13:28 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/87155 (The current URI for this page, for reference purposes)
Mauger, Alexis R.: https://orcid.org/0000-0001-6685-5800
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