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Supramolecular Self-associating Amphiphiles (SSAs) as enhancers of antimicrobial agents towards Escherichia coli (E. coli)

Boles, Jessica E., Ellaby, Rebecca J., Shepherd, Helena J., Hiscock, Jennifer R. (2021) Supramolecular Self-associating Amphiphiles (SSAs) as enhancers of antimicrobial agents towards Escherichia coli (E. coli). RSC Advances, 11 . pp. 9550-9556. E-ISSN 2046-2069. (doi:10.1039/D1RA00998B) (KAR id:86793)

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http://dx.doi.org/10.1039/D1RA00998B

Abstract

Supramolecular self-associating amphiphiles (SSAs) are a class of amphiphilic salt which have demonstrated antimicrobial activity against both Gram-positive and Gram-negative bacteria. Herein, we show that SSAs are also able to increase the efficacy of a range of currently used antimicrobial/therapeutic agents with a range of different chemical structures and modes of antimicrobial action against Gram-negative Escherichia coli, which include: octenidine (an antiseptic); ampicillin (an antibiotic); and cisplatin (a DNA chelating agent). Additionally, we show these effects to be dependent on the order of agent addition. Finally, through completion of a range of 1[thin space (1/6-em)]:[thin space (1/6-em)]1 SSA[thin space (1/6-em)]:[thin space (1/6-em)] antimicrobial/therapeutic agent physicochemical studies we gain an understanding as to how the self-association events and resultant SSA aggregate structure are effected by the presence of these secondary molecular species.

Item Type: Article
DOI/Identification number: 10.1039/D1RA00998B
Subjects: Q Science > QD Chemistry > QD431 Organic Chemistry- Biochemistry- Proteins, peptides, amino acids
Divisions: Divisions > Division of Natural Sciences > School of Physical Sciences
Depositing User: Jennifer Hiscock
Date Deposited: 26 Feb 2021 11:58 UTC
Last Modified: 06 Apr 2021 14:46 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/86793 (The current URI for this page, for reference purposes)
Shepherd, Helena J.: https://orcid.org/0000-0003-0832-4475
Hiscock, Jennifer R.: https://orcid.org/0000-0002-1406-8802
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