Carnell, George W., Trombetta, Claudia M., Ferrara, Francesca, Montomoli, Emanuele, Temperton, Nigel J. (2021) Correlation of Influenza B Haemagglutination Inhibiton, Single-Radial Haemolysis and Pseudotype-Based Microneutralisation Assays for Immunogenicity Testing of Seasonal Vaccines. Vaccines, 9 (2). Article Number 100. E-ISSN 2076-393X. (doi:10.3390/vaccines9020100) (KAR id:85745)
PDF
Publisher pdf
Language: English
This work is licensed under a Creative Commons Attribution 4.0 International License.
|
|
Download this file (PDF/6MB) |
Preview |
Request a format suitable for use with assistive technology e.g. a screenreader | |
Official URL: https://dx.doi.org/10.3390/vaccines9020100 |
Abstract
Influenza B is responsible for a significant proportion of the global morbidity, mortality and economic loss caused by influenza-related disease. Two antigenically distinct lineages co-circulate worldwide, often resulting in mismatches in vaccine coverage when vaccine predictions fail. There are currently operational issues with gold standard serological assays for influenza B, such as lack of sensitivity and requirement for specific antigen treatment. This study encompasses the gold standard assays with the more recent Pseudotype-based Microneutralisation assay in order to study comparative serological outcomes. Haemagglutination Inhibition, Single Radial Haemolysis and Pseudotype-based Microneutralisation correlated strongly for strains in the Yamagata lineage; however, it correlated with neither gold standard assays for the Victoria lineage.
Item Type: | Article |
---|---|
DOI/Identification number: | 10.3390/vaccines9020100 |
Uncontrolled keywords: | influenza B viruses; serology |
Subjects: | Q Science > QR Microbiology > QR355 Virology |
Divisions: | Divisions > Division of Natural Sciences > Medway School of Pharmacy |
Depositing User: | Nigel Temperton |
Date Deposited: | 29 Jan 2021 12:41 UTC |
Last Modified: | 14 Nov 2022 23:11 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/85745 (The current URI for this page, for reference purposes) |
- Link to SensusAccess
- Export to:
- RefWorks
- EPrints3 XML
- BibTeX
- CSV
- Depositors only (login required):