Skip to main content

Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection

Reynolds, Catherine J., Swadling, Leo, Gibbons, Joseph M., Pade, Corinna, Jensen, Melanie P., Diniz, Mariana O., Schmidt, Nathalie M., Butler, David K., Amin, Oliver E., Bailey, Sasha N. L., and others. (2020) Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection. Science Immunology, 5 (54). Article Number eabf3698. E-ISSN 2470-9468. (doi:10.1126/sciimmunol.abf3698) (KAR id:85663)

PDF Publisher pdf
Language: English


Download (2MB) Preview
[thumbnail of eabf3698.full.pdf]
Preview
This file may not be suitable for users of assistive technology.
Request an accessible format
Official URL
https://doi.org/10.1126/sciimmunol.abf3698

Abstract

Understanding the nature of immunity following mild/asymptomatic infection with SARS-CoV-2 is crucial to controlling the pandemic. We analyzed T cell and neutralizing antibody responses in 136 healthcare workers (HCW) 16-18 weeks after United Kingdom lockdown, 76 of whom had mild/asymptomatic SARS-CoV-2 infection captured by serial sampling. Neutralizing antibodies (nAb) were present in 89% of previously infected HCW. T cell responses tended to be lower following asymptomatic infection than in those reporting case-definition symptoms of COVID-19, while nAb titers were maintained irrespective of symptoms. T cell and antibody responses were sometimes discordant. Eleven percent lacked nAb and had undetectable T cell responses to spike protein but had T cells reactive with other SARS-CoV-2 antigens. Our findings suggest that the majority of individuals with mild or asymptomatic SARS-CoV-2 infection carry nAb complemented by multispecific T cell responses at 16-18 weeks after mild or asymptomatic SARS-CoV-2 infection.

Item Type: Article
DOI/Identification number: 10.1126/sciimmunol.abf3698
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Nigel Temperton
Date Deposited: 25 Jan 2021 15:15 UTC
Last Modified: 16 Feb 2021 14:17 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/85663 (The current URI for this page, for reference purposes)
Temperton, Nigel: https://orcid.org/0000-0002-7978-3815
  • Depositors only (login required):

Downloads

Downloads per month over past year