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The periaqueductal grey modulates sensory input to the cerebellum: a role in coping behaviour?

Cerminara, N L, Koutsikou, Stella, Lumb, B M, Apps, R (2009) The periaqueductal grey modulates sensory input to the cerebellum: a role in coping behaviour? European Journal of Neuroscience, 29 (11). pp. 2197-2206. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:84447)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
https://doi.org/10.1111/j.1460-9568.2009.06760.x

Abstract

The paths that link the periaqueductal grey (PAG) to hindbrain motor circuits underlying changes in behavioural responsiveness to external stimuli are unknown. A major candidate structure for mediating these effects is the cerebellum. The present experiments test this directly by monitoring changes in size of cerebellar responses evoked by peripheral stimuli following activation of the PAG. In 22 anaesthetized adult Wistar rats, climbing fibre field potentials were recorded from the C1 zone in the paramedian lobule and the copula pyramidis of the cerebellar cortex evoked, respectively, by electrical stimulation of the ipsilateral fore‐ and hindlimb. An initial and a late response were attributable to activation of Aβ and Aδ peripheral afferents respectively (hindlimb onset latencies 16.9 and 23.8 ms). Chemical stimulation at physiologically‐identified sites in the ventrolateral PAG (a region known to be associated with hyporeactive immobility) resulted in a significant reduction in size of both the Aβ and Aδ evoked field potentials (mean reduction relative to control ± SEM, 59 ± 7.5 and 66 ± 11.9% respectively). Responses evoked by electrical stimulation of the dorsal or ventral funiculus of the spinal cord were also reduced by PAG stimulation, suggesting that part of the modulation may occur at supraspinal sites (including at the level of the inferior olive). Overall, the results provide novel evidence of descending control into motor control centres, and provide the basis for future studies into the role of the PAG in regulating motor activity in different behavioural states and in chronic pain.

Item Type: Article
Subjects: Q Science > QP Physiology (Living systems)
R Medicine > RC Internal medicine > RC321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Stella Koutsikou
Date Deposited: 25 Nov 2020 13:10 UTC
Last Modified: 16 Feb 2021 14:16 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/84447 (The current URI for this page, for reference purposes)
Koutsikou, Stella: https://orcid.org/0000-0003-2933-3637
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