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The olivo-cerebellar system and its relationship to survival circuits

Watson, T C and Koutsikou, Stella and Cerminara, N L and Flavell, C R and Crook, J J and Lumb, B M and Apps, R (2013) The olivo-cerebellar system and its relationship to survival circuits. Frontiers in Neural Circuits, 7 . pp. 304-310. (KAR id:84444)

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Official URL
https://doi.org/10.3389/fncir.2013.00072

Abstract

How does the cerebellum, the brain's largest sensorimotor structure, contribute to complex behaviors essential to survival? While we know much about the role of limbic and closely associated brainstem structures in relation to a variety of emotional, sensory, or motivational stimuli, we know very little about how these circuits interact with the cerebellum to generate appropriate patterns of behavioral response. Here we focus on evidence suggesting that the olivo-cerebellar system may link to survival networks via interactions with the midbrain periaqueductal gray, a structure with a well known role in expression of survival responses. As a result of this interaction we argue that, in addition to important roles in motor control, the inferior olive, and related olivo-cortico-nuclear circuits, should be considered part of a larger network of brain structures involved in coordinating survival behavior through the selective relaying of "teaching signals" arising from higher centers associated with emotional behaviors.

Item Type: Review
Subjects: Q Science > QP Physiology (Living systems)
R Medicine > RC Internal medicine > RC321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Stella Koutsikou
Date Deposited: 25 Nov 2020 12:31 UTC
Last Modified: 16 Nov 2021 10:27 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/84444 (The current URI for this page, for reference purposes)
Koutsikou, Stella: https://orcid.org/0000-0003-2933-3637
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