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Limitations of a time-lapse blastocyst prediction model: a large multicentre outcome analysis

Kirkegaard, Kirstine, Campbell, Alison, Agerholm, Inge, Bentin-Ley, Ursula, Gabrielsen, Anette, Kirk, John, Sayed, Shabana, Ingerslev, Hans Jakob (2014) Limitations of a time-lapse blastocyst prediction model: a large multicentre outcome analysis. Reproductive BioMedicine Online, 29 (2). pp. 156-158. ISSN 1472-6483. (doi:10.1016/j.rbmo.2014.04.011) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:84031)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
https://doi.org/10.1016/j.rbmo.2014.04.011

Abstract

The goal of embryo selection models is to select embryos with the highest reproductive potential, whilst minimizing the rejection of viable embryos. Ultimately, any embryo selection model must be tested on clinical outcome. We therefore retrospectively tested a published blastocyst prediction model on a large combined set of transferred embryos with known clinical outcome. The model was somewhat effective in that we found a relative increase of 30% for implantation in the model-selected group of embryos. There was, however, a concomitant large rejection of embryos from our test cohort, which actually resulted in pregnancy. This hypothetical experiment highlights the limitations of predicting blastulation only. Crucially, it illustrates that both sensitivity and specificity are important parameters when developing embryo selection models for prospective clinical use.

Item Type: Article
DOI/Identification number: 10.1016/j.rbmo.2014.04.011
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > School of Biosciences
Depositing User: Alison Campbell
Date Deposited: 10 Nov 2020 12:14 UTC
Last Modified: 10 Nov 2020 12:15 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/84031 (The current URI for this page, for reference purposes)
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