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Towards the prediction of antimicrobial efficacy for hydrogen bonded, self-associating amphiphiles

Allen, Nyasha, White, Lisa J., Boles, Jessica E., Williams, George T., Chu, Dominique, Ellaby, Rebecca J., Shepherd, H.J., Ng, Kendrick K. L., Blackholly, Laura R., Wilson, B., and others. (2020) Towards the prediction of antimicrobial efficacy for hydrogen bonded, self-associating amphiphiles. ChemMedChem, . ISSN 1860-7179. (doi:10.1002/cmdc.202000533) (KAR id:83798)

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Abstract

Herein, we report 50 structurally related supramolecular self-associating amphiphilic (SSA) salts and related compounds. These SSAs are shown to act as antimicrobial agents, active against model Gram-positive (Methicillin-Resistant Staphylococcus aureus) and/or Gram-negative (Escherichia coli) bacteria of clinical interest. Through a combination of solution state, gas phase, solid state and in silico measurements we determine 14 different physicochemical parameters for each of these 50 structurally related compounds. These parameter sets are then used to identify molecular structure – physicochemical property – antimicrobial activity relationships for our model Gram-negative and Gram-positive bacteria, while simultaneously providing insight towards the elucidation of SSA mode of antimicrobial action.

Item Type: Article
DOI/Identification number: 10.1002/cmdc.202000533
Uncontrolled keywords: Antimicrobial, Amphiphiles, Supramolecular, Chemistry Hydrogen bonds, Structure-activity relationships
Subjects: Q Science
Q Science > QD Chemistry
Q Science > QD Chemistry > QD431 Organic Chemistry- Biochemistry- Proteins, peptides, amino acids
Divisions: Divisions > Division of Natural Sciences > School of Biosciences
Divisions > Division of Natural Sciences > School of Physical Sciences
Depositing User: Jennifer Hiscock
Date Deposited: 28 Oct 2020 14:46 UTC
Last Modified: 16 Feb 2021 14:15 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/83798 (The current URI for this page, for reference purposes)
Chu, Dominique: https://orcid.org/0000-0002-3706-2905
Shepherd, H.J.: https://orcid.org/0000-0003-0832-4475
Mulvihill, Daniel P.: https://orcid.org/0000-0003-2502-5274
Hiscock, Jennifer R.: https://orcid.org/0000-0002-1406-8802
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