Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020

Thompson, Craig P, Grayson, Nicholas E, Paton, Robert S, Bolton, Jai S, Lourenço, José, Penman, Bridget S, Lee, Lian N, Odon, Valerie, Mongkolsapaya, Juthathip, Chinnakannan, Senthil, and others. (2020) Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020. Eurosurveillance, 25 (42). pp. 1-9. ISSN 1560-7917. (doi:10.2807/1560-7917.ES.2020.25.42.2000685) (KAR id:83760)

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Official URL: https://doi.org/10.2807/1560-7917.ES.2020.25.42.20...

Abstract

BackgroundThe progression and geographical distribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the United Kingdom (UK) and elsewhere is unknown because typically only symptomatic individuals are diagnosed. We performed a serological study of blood donors in Scotland in the spring of 2020 to detect neutralising antibodies to SARS-CoV-2 as a marker of past infection and epidemic progression.AimOur objective was to determine if sera from blood bank donors can be used to track the emergence and progression of the SARS-CoV-2 epidemic.MethodsA pseudotyped SARS-CoV-2 virus microneutralisation assay was used to detect neutralising antibodies to SARS-CoV-2. The study comprised samples from 3,500 blood donors collected in Scotland between 17 March and 18 May 2020. Controls were collected from 100 donors in Scotland during 2019.ResultsAll samples collected on 17 March 2020 (n = 500) were negative in the pseudotyped SARS-CoV-2 virus microneutralisation assay. Neutralising antibodies were detected in six of 500 donors from 23 to 26 March. The number of samples containing neutralising antibodies did not significantly rise after 5-6 April until the end of the study on 18 May. We found that infections were concentrated in certain postcodes, indicating that outbreaks of infection were extremely localised. In contrast, other areas remained comparatively untouched by the epidemic.ConclusionAlthough blood donors are not representative of the overall population, we demonstrated that serosurveys of blood banks can serve as a useful tool for tracking the emergence and progression of an epidemic such as the SARS-CoV-2 outbreak.

Item Type:	Article
DOI/Identification number:	10.2807/1560-7917.ES.2020.25.42.2000685
Subjects:	Q Science > QR Microbiology > QR355 Virology
Divisions:	Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User:	Nigel Temperton
Date Deposited:	27 Oct 2020 11:18 UTC
Last Modified:	24 Sep 2022 22:09 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/83760 (The current URI for this page, for reference purposes)

University of Kent Author Information

Temperton, Nigel J..

Creator's ORCID:	https://orcid.org/0000-0002-7978-3815
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