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Drug–Smectite Clay Amorphous Solid Dispersions Processed by Hot Melt Extrusion

Nandi, Uttom, Mithu, Md. S. H., Hurt, Andrew P., Trivedi, Vivek, Douroumis, Dennis (2020) Drug–Smectite Clay Amorphous Solid Dispersions Processed by Hot Melt Extrusion. AAPS PharmSciTech, 21 . Article Number 276. ISSN 1530-9932. (doi:10.1208/s12249-020-01813-x) (KAR id:83441)


The aim of this study was to investigate suitability of natural and synthetic smectite clay matrices as a drug delivery carrier for the development of amorphous solid dispersions (ASD). Indomethacin (IND) was processed with two different smectite clays, natural-magnesium aluminium and synthetic-lithium magnesium sodium silicates, using Hot Melt Extrusion (HME) to prepare solid dispersions. Scanning electron microscopy (SEM), Powdered X-ray diffraction (PXRD), Differential scanning calorimetry (DSC) were used to examine the physical form of the drug. Energy dispersive X-ray spectroscopy (EDX) was used to investigate the drug distribution and Attenuated Total Reflectance-Fourier transform infrared (ATR-FTIR) spectroscopic analysis was done to detect any chemical interaction between these two kinds. Both, PXRD and DSC analysis showed that drug-clay solid dispersion contained IND in amorphous form. Energy dispersive X-ray (EDX) analysis showed a uniform IND dispersion in the extruded powders. ATR-FTIR data presented possible drug and clay interactions via hydrogen bonding. In-vitro drug dissolution studies revealed a lag time of about two hours in the acidic media and a rapid release of IND at pH 7.4. The work demonstrated that preparation of amorphous solid dispersion using inorganic smectite clay particles can effectively increase the dissolution rate of IND.

Item Type: Article
DOI/Identification number: 10.1208/s12249-020-01813-x
Uncontrolled keywords: Indomethacin, clay, hot-melt extrusion, dissolution, solid dispersion
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Vivek Trivedi
Date Deposited: 14 Oct 2020 13:40 UTC
Last Modified: 09 Dec 2022 05:50 UTC
Resource URI: (The current URI for this page, for reference purposes)

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