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Selective antagonism of cJun for cancer therapy

Brennan, Andrew, Leech, James T., Kad, Neil M., Mason, Jody M. (2020) Selective antagonism of cJun for cancer therapy. Journal of Experimental & Clinical Cancer Research, 39 (1). Article Number 184. ISSN 1756-9966. (doi:10.1186/s13046-020-01686-9) (KAR id:83337)

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https://doi.org/10.1186/s13046-020-01686-9

Abstract

The activator protein-1 (AP-1) family of transcription factors modulate a diverse range of cellular signalling pathways into outputs which can be oncogenic or anti-oncogenic. The transcription of relevant genes is controlled by the cellular context, and in particular by the dimeric composition of AP-1. Here, we describe the evidence linking cJun in particular to a range of cancers. This includes correlative studies of protein levels in patient tumour samples and mechanistic understanding of the role of cJun in cancer cell models. This develops an understanding of cJun as a focal point of cancer-altered signalling which has the potential for therapeutic antagonism. Significant work has produced a range of small molecules and peptides which have been summarised here and categorised according to the binding surface they target within the cJun-DNA complex. We highlight the importance of selectively targeting a single AP-1 family member to antagonise known oncogenic function and avoid antagonism of anti-oncogenic function.

Item Type: Article
DOI/Identification number: 10.1186/s13046-020-01686-9
Uncontrolled keywords: c-Jun; Activator Protein-1; transcriptional regulator; basic leucine zipper; cancer; peptides; protein-protein interaction
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Neil Kad
Date Deposited: 08 Oct 2020 16:01 UTC
Last Modified: 08 Oct 2020 16:01 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/83337 (The current URI for this page, for reference purposes)
Kad, Neil M.: https://orcid.org/0000-0002-3491-8595
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