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The psychological impact of undergoing genetic-risk profiling in men with a family history of prostate cancer

Bancroft, Elizabeth K., Castro, Elena, Bancroft, Gordon A., Ardern-Jones, Audrey, Moynihan, Clare, Page, Elizabeth, Taylor, Natalie, Eeles, Rosalind A., Rowley, Emma, Cox, Karen and others. (2015) The psychological impact of undergoing genetic-risk profiling in men with a family history of prostate cancer. Psycho-Oncology, 24 (11). pp. 1492-1499. ISSN 1057-9249. (doi:10.1002/pon.3814) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:83181)

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Abstract

Background: The ability to identify men at genetically high‐risk of prostate cancer (PrCa) would enable screening to be targeted at those most in need. This study explored the psychological impact (in terms of general and PrCa‐specific worry and risk perceptions) on men with a family history of PrCa, undergoing prostate screening and genetic‐risk profiling, within a research study. Methods: A prospective exploratory approach was adopted, incorporating a sequential mixed‐method design. Questionnaires were completed at two time points to measure the impact of undergoing screening and genetic‐risk profiling. In‐depth interviews were completed in a subgroup after all study procedures were completed and analysed using a framework approach. Results: Ninety‐five men completed both questionnaires, and 26 were interviewed. No measurable psychological distress was detectable in the group as a whole. The interview findings fell into two categories: ‘feeling at risk’ and ‘living with risk’. The feeling of being at risk of PrCa is a part of men's lives, shaped by assumptions and information gathered over many years. Men used this information to communicate about PrCa risk to their peers. Men overestimate their risk of PrCa and have an innate assumption that they will develop PrCa. The interviews revealed that men experienced acute anxiety when waiting for screening results. Conclusions: Personalised genetic‐risk assessments do not prevent men from overestimating their risk of PrCa. Screening anxiety is common, and timeframes for receiving results should be kept to a minimum. Methods of risk communication in men at risk of PrCa should be the subject of future research.

Item Type: Article
DOI/Identification number: 10.1002/pon.3814
Divisions: Central Services > Office of the Vice-Chancellor
Depositing User: Karen Cox
Date Deposited: 29 Sep 2020 09:40 UTC
Last Modified: 16 Feb 2021 14:15 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/83181 (The current URI for this page, for reference purposes)
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