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Gene Expression Signature of Acquired Chemoresistance in Neuroblastoma Cells

Jemaà, Mohamed, Sime, Wondossen, Abassi, Yasmin, Lasorsa, Vito Alessandro, Bonne Køhler, Julie, Michaelis, Martin, Cinatl, Jindrich, Capasso, Mario, Massoumi, Ramin (2020) Gene Expression Signature of Acquired Chemoresistance in Neuroblastoma Cells. International Journal of Molecular Sciences, 21 (18). Article Number 6811. ISSN 1661-6596. E-ISSN 1422-0067. (doi:10.3390/ijms21186811) (KAR id:83143)

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https://dx.doi.org/10.3390/ijms21186811

Abstract

Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. Patients with relapsed disease have a poor prognosis despite intense treatment. In the present study, we aimed

reduced serum conditions as compared with non-resistant parental cells. To identify the possible mechanisms underlying vincristine resistance in neuroblastoma cells, we investigated the expression

profiles of genes known to be involved in cancer drug resistance. This specific gene expression patterns could predict the behavior of a tumor in response to chemotherapy and for predicting the prognosis of high-risk neuroblastoma patients. Our signature could help chemoresistant neuroblastoma patients in avoiding useless and harmful chemotherapy cycles.

Item Type: Article
DOI/Identification number: 10.3390/ijms21186811
Uncontrolled keywords: chemoresistance; neuroblastoma; vincristine
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Divisions > Division of Natural Sciences > School of Biosciences
Depositing User: Martin Michaelis
Date Deposited: 26 Sep 2020 17:22 UTC
Last Modified: 28 Sep 2020 09:28 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/83143 (The current URI for this page, for reference purposes)
Michaelis, Martin: https://orcid.org/0000-0002-5710-5888
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