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Murine in vitro cellular models to better understand adipogenesis and its potential applications

Vohra, Muhammad Sufyan, Ahmad, Bilal, Serpell, Christopher J., Parhar, Ishwar S., Wong, Eng Hwa (2020) Murine in vitro cellular models to better understand adipogenesis and its potential applications. Differentiation, 115 . pp. 62-84. ISSN 0301-4681. (doi:10.1016/j.diff.2020.08.003) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:82817)

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Language: English

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https://doi.org/10.1016/j.diff.2020.08.003

Abstract

Adipogenesis has been extensively studied using in vitro models of cellular differentiation, enabling long-term regulation of fat cell metabolism in human adipose tissue (AT) material. Many studies promote the idea that manipulation of this process could potentially reduce the prevalence of obesity and its related diseases. It has now become essential to understand the molecular basis of fat cell development to tackle this pandemic disease, by identifying therapeutic targets and new biomarkers. This review explores murine cell models and their applications for study of the adipogenic differentiation process in vitro. We focus on the benefits and limitations of different cell line models to aid in interpreting data and selecting a good cell line model for successful understanding of adipose biology.

Item Type: Article
DOI/Identification number: 10.1016/j.diff.2020.08.003
Uncontrolled keywords: Adipose tissue, Adipogenesis, Cellular models, Differentiation, Anti-obesity
Subjects: Q Science
Divisions: Faculties > Sciences > School of Physical Sciences
Depositing User: Christopher Serpell
Date Deposited: 08 Sep 2020 15:52 UTC
Last Modified: 08 Sep 2020 15:52 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/82817 (The current URI for this page, for reference purposes)
Serpell, Christopher J.: https://orcid.org/0000-0002-2848-9077
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