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COVID-19-Related Coagulopathy—Is Transferrin a Missing Link?

McLaughlin, Katie-May, Bechtel, Marco, Bojkova, Denisa, Münch, Christian, Ciesek, Sandra, Wass, Mark N., Michaelis, Martin, Cinatl, Jindrich (2020) COVID-19-Related Coagulopathy—Is Transferrin a Missing Link? Diagnostics, 10 (8). p. 539. ISSN 2075-4418. (doi:10.3390/diagnostics10080539) (KAR id:82372)

Abstract

SARS-CoV-2 is the causative agent of COVID-19. Severe COVID-19 disease has been associated with disseminated intravascular coagulation and thrombosis, but the mechanisms underlying COVID-19-related coagulopathy remain unknown. The risk of severe COVID-19 disease is higher in males than in females and increases with age. To identify gene products that may contribute to COVID-19-related coagulopathy, we analyzed the expression of genes associated with the Gene Ontology (GO) term “blood coagulation” in the Genotype-Tissue Expression (GTEx) database and identified four procoagulants, whose expression is higher in males and increases with age (ADAMTS13, F11, HGFAC, KLKB1), and two anticoagulants, whose expression is higher in females and decreases with age (C1QTNF1, SERPINA5). However, the expression of none of these genes was regulated in a proteomics dataset of SARS-CoV-2-infected cells and none of the proteins have been identified as a binding partner of SARS-CoV-2 proteins. Hence, they may rather generally predispose individuals to thrombosis without directly contributing to COVID-19-related coagulopathy. In contrast, the expression of the procoagulant transferrin (not associated to the GO term “blood coagulation”) was higher in males, increased with age, and was upregulated upon SARS-CoV-2 infection. Hence, transferrin warrants further examination in ongoing clinic-pathological investigations

Item Type: Article
DOI/Identification number: 10.3390/diagnostics10080539
Uncontrolled keywords: SARS-CoV-2, COVID-19, thrombosis, coagulation, coagulopathy, transferrin
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Divisions > Division of Natural Sciences > School of Biosciences
Depositing User: Martin Michaelis
Date Deposited: 05 Aug 2020 05:34 UTC
Last Modified: 06 Aug 2020 08:13 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/82372 (The current URI for this page, for reference purposes)
Wass, Mark N.: https://orcid.org/0000-0001-5428-6479
Michaelis, Martin: https://orcid.org/0000-0002-5710-5888
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