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Anodal tDCS Over the Left Prefrontal Cortex Does Not Cause Clinically Significant Changes in Circulating Metabolites

Kortteenniemi, Aaron, Ortega-Alonso, Alfredo, Javadi, Amir-Homayoun, Tolmunen, Tommi, Ali-Sisto, Toni, Kotilainen, Tuukka, Wikgren, Jan, Karhunen, Leila, Velagapudi, Vidya, Lehto, Soili M. and others. (2020) Anodal tDCS Over the Left Prefrontal Cortex Does Not Cause Clinically Significant Changes in Circulating Metabolites. Frontiers in Psychiatry, 11 . ISSN 1664-0640. (doi:10.3389/fpsyt.2020.00403) (KAR id:81295)

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https://doi.org/10.3389/fpsyt.2020.00403

Abstract

Background: Transcranial direct current stimulation (tDCS), a putative treatment for depression, has been proposed to affect peripheral metabolism. Metabolic products from brain tissue may also cross the blood–brain barrier, reflecting the conditions in the brain. However, there are no previous data regarding the effect of tDCS on circulating metabolites.

Methods: This double-blind, randomized controlled trial involved 79 healthy males (aged 20–40 years) divided into two groups, one receiving tDCS (2 mA) and the other sham stimulated. The anode was placed over the left dorsolateral prefrontal cortex and the cathode over the corresponding contralateral area. Venous blood samples were obtained before and after the first stimulation session, and after the fifth stimulation session. Serum levels of 102 metabolites were determined by mass spectrometry. The results were analysed with generalised estimating equations corrected for the family-wise error rate. In addition, we performed power calculations estimating sample sizes necessary for future research.

Conclusion: Our study found that five sessions of tDCS induced no major effects on peripheral metabolites among healthy men. These observations support the view of tDCS as a safe treatment that does not induce significant changes in the measured peripheral metabolites in healthy male subjects.

Item Type: Article
DOI/Identification number: 10.3389/fpsyt.2020.00403
Uncontrolled keywords: brain stimulation, transcranial direct current stimulation, tES, metabolism, mass spectrometry
Divisions: Divisions > Division of Human and Social Sciences > School of Psychology
Depositing User: Amir-Homayoun Javadi
Date Deposited: 18 May 2020 11:15 UTC
Last Modified: 16 Feb 2021 14:13 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/81295 (The current URI for this page, for reference purposes)
Javadi, Amir-Homayoun: https://orcid.org/0000-0003-0569-6441
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