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NPR1 Modulates Cross-Talk between Salicylate- and Jasmonate-Dependent Defense Pathways through a Novel Function in the Cytosol

Spoel, Steven H., Koornneef, Annemart, Claessens, Susanne M. C., Korzelius, Jerome, Van Pelt, Johan A., Mueller, Martin J., Buchala, Antony J., Métraux, Jean-Pierre, Brown, Rebecca, Kazan, Kemal, and others. (2003) NPR1 Modulates Cross-Talk between Salicylate- and Jasmonate-Dependent Defense Pathways through a Novel Function in the Cytosol. Plant Cell, 15 (3). pp. 760-770. ISSN 1040-4651. (doi:10.1105/tpc.009159) (KAR id:81272)

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Official URL:
https://doi.org/10.1105/tpc.009159

Abstract

Plant defenses against pathogens and insects are regulated differentially by cross-communicating signal transduction pathways in which salicylic acid (SA) and jasmonic acid (JA) play key roles. In this study, we investigated the molecular mechanism of the antagonistic effect of SA on JA signaling. Arabidopsis plants unable to accumulate SA produced 25-fold higher levels of JA and showed enhanced expression of the JA-responsive genes LOX2, PDF1.2, and VSP in response to infection by Pseudomonas syringae pv tomato DC3000, indicating that in wild-type plants, pathogen-induced SA accumulation is associated with the suppression of JA signaling. Analysis of the Arabidopsis mutant npr1, which is impaired in SA signal transduction, revealed that the antagonistic effect of SA on JA signaling requires the regulatory protein NPR1. Nuclear localization of NPR1, which is essential for SA-mediated defense gene expression, is not required for the suppression of JA signaling, indicating that cross-talk between SA and JA is modulated through a novel function of NPR1 in the cytosol.

Item Type: Article
DOI/Identification number: 10.1105/tpc.009159
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Susan Davies
Date Deposited: 15 May 2020 15:26 UTC
Last Modified: 16 Nov 2021 10:26 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/81272 (The current URI for this page, for reference purposes)
Korzelius, Jerome: https://orcid.org/0000-0002-8443-0192
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