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Controllable hydrogen bonded self-association for the formation of multifunctional antimicrobial materials

White, Lisa, Boles, Jessica E., Allen, Nyasha, Alesbrook, Luke, Sutton, J. Mark, Hind, Charlotte, Hilton, Kira, Blackholly, Laura R., Ellaby, Rebecca, Williams, George, and others. (2020) Controllable hydrogen bonded self-association for the formation of multifunctional antimicrobial materials. Journal of Materials Chemistry B, 8 . pp. 4694-4700. ISSN 2050-750X. E-ISSN 2050-7518. (doi:10.1039/D0TB00875C) (KAR id:81118)

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SSAs are a class of Supramolecular Self-associating Amphiphilic salt, the anionic component of which contains a covalently bound hydrogen bond donor-acceptor motif. This results in a monomeric unit which can adopt multiple hydrogen bonding modes simultaneously. Previous investigations have shown examples of SSAs to act as antimicrobial agents against clinically relevant methicillin-resistant Staphylococcus aureus (MRSA). Herein, we report an intrinsically fluorescent SSA which can self-associate producing dimers, spherical aggregates and hydrogels dependent on solvent environment, while retaining antimicrobial activity against both model Gram-positive (MRSA) and Gram-negative (Escherichia coli) bacteria. Finally, we demonstrate the SSA supramolecular hydrogel to tolerate the inclusion of the antibiotic ampicillin, leading to the enhanced inhibition of growth with both model bacteria, and derive initial molecular structure-physicochemical property-antimicrobial activity relationships.

Item Type: Article
DOI/Identification number: 10.1039/D0TB00875C
Subjects: Q Science > QD Chemistry
Divisions: Divisions > Division of Natural Sciences > School of Physical Sciences
Depositing User: Jennifer Hiscock
Date Deposited: 04 May 2020 14:49 UTC
Last Modified: 03 May 2021 23:00 UTC
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Mulvihill, Daniel P.:
Hiscock, Jennifer Ruth:
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