Skip to main content

Interplay of mitochondrial fission-fusion with cell cycle regulation: Possible impacts on stem cell and organismal aging

Spurlock, B., Tullet, J.M.A., Hartman, J.L., Mitra, K. (2020) Interplay of mitochondrial fission-fusion with cell cycle regulation: Possible impacts on stem cell and organismal aging. Experimental Gerontology, 135 . p. 110919. ISSN 0531-5565. (doi:10.1016/j.exger.2020.110919) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:80703)

PDF Author's Accepted Manuscript
Language: English

Restricted to Repository staff only

Creative Commons Licence
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Contact us about this Publication
[img]
Official URL
https://doi.org/10.1016/j.exger.2020.110919

Abstract

Declining mitochondrial function and homeostasis is a hallmark of aging. It is appreciated that the role of mitochondria is much more complex than generating reactive oxygen species to cause aging-related tissue damage. More recent literature describes that the ability of mitochondria to undergo fission or fusion events with each other impacts aging processes. A dynamic balance of mitochondrial fission and fusion events is required to sustain critical cellular functions including cell cycle. Specifically, cell cycle regulators modulate molecular activities of the mitochondrial fission (and fusion) machinery towards regulating cell cycle progression. In this review, we discus literature leading to our understanding on how shifts in the dynamic balance of mitochondrial fission and fusion can modulate progression through, exit from, and re-entry to the cell cycle or undergo senescence. Importantly, core regulators of mitochondrial fission or fusion are emerging as crucial stem cell regulators. We discuss the implication of such regulation in stem cells in the context of aging, given that aberrations in adult stem cells promote aging. We also propose a few hypotheses that may provide direction for further understanding about the roles of mitochondrial fission-fusion dynamics in aging biology.

Item Type: Article
DOI/Identification number: 10.1016/j.exger.2020.110919
Subjects: Q Science
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Jennifer Tullet
Date Deposited: 02 Apr 2020 12:55 UTC
Last Modified: 23 Apr 2020 14:22 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/80703 (The current URI for this page, for reference purposes)
Tullet, J.M.A.: https://orcid.org/0000-0002-2037-526X
  • Depositors only (login required):

Downloads

Downloads per month over past year