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Sedation Modulates Frontotemporal Predictive Coding Circuits and the Double Surprise Acceleration Effect

Witon, Adrien, Shirazibeheshti, Amirali, Cooke, Jennifer, Aviles, Alberto, Adapa, Ram, Menon, David K., Chennu, Srivas, Bekinschtein, Tristan A., David Lopez, Jose, Litvak, Vladimir, and others. (2020) Sedation Modulates Frontotemporal Predictive Coding Circuits and the Double Surprise Acceleration Effect. Cerebral Cortex, . ISSN 1047-3211. E-ISSN 1460-2199. (doi:10.1093/cercor/bhaa071) (KAR id:80568)

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Two important theories in cognitive neuroscience are predictive coding and the global workspace theory. A key research task is to understand how these two theories relate to one another, and particularly, how the brain transitions from a predictive early state to the eventual engagement of a brain-scale state (the global workspace). To address this question, we present a source-localisation of EEG responses evoked by the local-global task – an experimental paradigm that engages a predictive hierarchy, which encompasses the global workspace. The results of our source reconstruction suggest three-phases of processing. The first phase involves the sensory (here auditory) regions of the superior temporal lobe and predicts sensory regularities over a short timeframe (as per the local effect). The third phase is brain-scale, involving inferior frontal, as well as inferior and superior parietal regions; consistent with a global neuronal workspace (as per the global effect). Crucially, our analysis suggests that there is an intermediate (second) phase, involving modulatory interactions between inferior frontal and superior temporal regions. Furthermore, sedation with propofol reduces modulatory interactions in the second phase. This selective effect is consistent with a predictive coding explanation of sedation, with propofol acting on descending predictions of the precision of prediction errors; thereby constraining access to the global neuronal workspace.

Item Type: Article
DOI/Identification number: 10.1093/cercor/bhaa071
Uncontrolled keywords: Predictive coding, sedation, source localisation, global workspace, event related potentials.
Subjects: H Social Sciences
Q Science > QP Physiology (Living systems)
Divisions: Divisions > Division of Computing, Engineering and Mathematical Sciences > School of Computing
Funders: Engineering and Physical Sciences Research Council (
Depositing User: Howard Bowman
Date Deposited: 21 Mar 2020 21:17 UTC
Last Modified: 04 Mar 2024 15:15 UTC
Resource URI: (The current URI for this page, for reference purposes)

University of Kent Author Information

Witon, Adrien.

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Shirazibeheshti, Amirali.

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Cooke, Jennifer.

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Chennu, Srivas.

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Li, Ling.

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Bowman, Howard.

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