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MyBP-C: one protein to govern them all

Heling, L. W. H. J., Geeves, M. A., Kad, N. M. (2020) MyBP-C: one protein to govern them all. Journal of Muscle Research and Cell Motility, . ISSN 0142-4319. E-ISSN 1573-2657. (doi:10.1007/s10974-019-09567-1) (KAR id:79662)

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https://doi.org/10.1007/s10974-019-09567-1

Abstract

The heart is an extraordinarily versatile pump, finely tuned to respond to a multitude of demands. Given the heart pumps without rest for decades its efficiency is particularly relevant. Although many proteins in the heart are essential for viability, the non-essential components can attract numerous mutations which can cause disease, possibly through alterations in pumping efficiency. Of these, myosin binding protein C is strongly over-represented with ~ 40% of all known mutations in hypertrophic cardiomyopathy. Therefore, a complete understanding of its molecular function in the cardiac sarcomere is warranted. In this review, we revisit contemporary and classical literature to clarify both the current standing of this fast-moving field and frame future unresolved questions. To date, much effort has been directed at understanding MyBP-C function on either thick or thin filaments. Here we aim to focus questions on how MyBP-C functions at a molecular level in the context of both the thick and thin filaments together. A concept that emerges is MyBP-C acts to govern interactions on two levels; controlling myosin access to the thin filament by sequestration on the thick filament, and controlling the activation state and access of myosin to its binding sites on the thin filament. Such affects are achieved through directed interactions mediated by phosphorylation (of MyBP-C and other sarcomeric components) and calcium.

Item Type: Article
DOI/Identification number: 10.1007/s10974-019-09567-1
Uncontrolled keywords: cMyBP-C Muscle contraction, Contractility, Cardiac Myosin, binding protein C
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Susan Davies
Date Deposited: 22 Jan 2020 09:04 UTC
Last Modified: 06 May 2020 03:20 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/79662 (The current URI for this page, for reference purposes)
Geeves, M. A.: https://orcid.org/0000-0002-9364-8898
Kad, N. M.: https://orcid.org/0000-0002-3491-8595
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