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Nottingham prognostic index plus (NPI+) predicts risk of distant metastases in primary breast cancer

Green, Andrew R., Soria, D., Powe, D.G., Nolan, C.C., Aleskandarany, M., Szász, M.A., Ball, G.R., Garibaldi, J.M., Rakha, E.A., Kulka, J., and others. (2016) Nottingham prognostic index plus (NPI+) predicts risk of distant metastases in primary breast cancer. Breast cancer research and treatment, 157 (1). pp. 65-75. ISSN 0167-6806. E-ISSN 1573-7217. (doi:10.1007/s10549-016-3804-1) (KAR id:79609)

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https://dx.doi.org/10.1007/s10549-016-3804-1

Abstract

The Nottingham prognostic index plus (NPI+) is based on the assessment of biological class combined with established clinicopathologic prognostic variables providing improved patient outcome stratification for breast cancer superior to the traditional NPI. This study aimed to determine prognostic capability of the NPI+ in predicting risk of development of distant disease. A well-characterised series of 1073 primary early-stage BC cases treated in Nottingham and 251 cases from Budapest were immunohistochemically assessed for cytokeratin (Ck)5/6, Ck18, EGFR, oestrogen receptor (ER), progesterone receptor, HER2, HER3, HER4, Mucin 1 and p53 expression. NPI+ biological class and prognostic scores were assigned using individual algorithms for each biological class incorporating clinicopathologic parameters and investigated in terms of prediction of distant metastases-free survival (MFS). The NPI+ identified distinct prognostic groups (PG) within each molecular class which were predictive of MFS providing improved patient outcome stratification superior to the traditional NPI. NPI+ PGs, between series, were comparable in predicting patient outcome between series in luminal A, basal p53 altered and HER2+/ER+ (p > 0.01) tumours. The low-risk groups were similarly validated in luminal B, luminal N, basal p53 normal tumours (p > 0.01). Due to small patient numbers the remaining PGs could not be validated. NPI+ was additionally able to predict a higher risk of metastases at certain distant sites. This study may indicate the NPI+ as a useful tool in predicting the risk of metastases. The NPI+ provides accurate risk stratification allowing improved individualised clinical decision making for breast cancer.

Item Type: Article
DOI/Identification number: 10.1007/s10549-016-3804-1
Uncontrolled keywords: Breast cancer, Classification, Prognostic index, Molecular, Clinical, Outcome
Subjects: Q Science > QA Mathematics (inc Computing science)
Divisions: Faculties > Sciences > School of Computing > Data Science
Depositing User: Daniel Soria
Date Deposited: 17 Jan 2020 15:53 UTC
Last Modified: 20 Jan 2020 11:49 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/79609 (The current URI for this page, for reference purposes)
Soria, D.: https://orcid.org/0000-0002-0164-8218
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