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Vestibular Influences on Neuropsychological Outcomes in UK Military Veterans with Mild Traumatic Brain Injury

Denby, Emma (2019) Vestibular Influences on Neuropsychological Outcomes in UK Military Veterans with Mild Traumatic Brain Injury. Doctor of Philosophy (PhD) thesis, University of Kent,.

Abstract

Abstract

In light of the newfound association between vestibular disturbance and mTBI, the remaining chapters sought to establish if and how artificial vestibular stimulation can remediate aspects of mTBI. To help determine whether to target positive or negative symptoms, in Chapter 4 I sought to determine if GVS could induce either long-term potentiation (LTP) or depression (LTD) type effects, in neurologically healthy individuals up to 24hours post stimulation. The results showed that in participants who demonstrated cortical hyperexcitability at baseline, GVS induced a significant LTD type effect at 24hours post-stimulation. This indicated that conditions such as anxiety and PTSD, which are associated with cortical hyperexcitability, should be targeted. In Chapter 5 a small proof of concept study evaluated the efficacy of GVS in treating current symptoms of anxiety in 5 UK military veterans. The results showed that state symptoms of anxiety were exacerbated at 24hours post active GVS, which although further introduces a link between the vestibular system and anxiety in mTBI, did not support therapeutic application of GVS. In Chapter 6, the general discussion concludes that, vestibular disturbance is predictive of poor long-term mental health and therefore needs to be routinely screened and treated. Further studies are also needed to establish how to yoke the novel effects of GVS on cortical excitability observed here for treatment of mTBI symptoms.

Item Type: Thesis (Doctor of Philosophy (PhD))
Thesis advisor: Wilkinson, David
Divisions: Faculties > Social Sciences > School of Psychology
SWORD Depositor: System Moodle
Depositing User: System Moodle
Date Deposited: 14 Jan 2020 10:10 UTC
Last Modified: 15 Jan 2020 14:17 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/79568 (The current URI for this page, for reference purposes)
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