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Growth, assembly and fragmentation mechanisms in the molecular life cycle of Sup35NM prion and alpha-synuclein amyloid particles

Barber, Jack (2019) Growth, assembly and fragmentation mechanisms in the molecular life cycle of Sup35NM prion and alpha-synuclein amyloid particles. Master of Research (MRes) thesis, University of Kent,. (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

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Abstract

With devastating diseases like Alzheimer's disease and Parkinson's disease rising in numbers, amyloid and prion research is steadily increasing. However, there are many questions that have yet to be answered. One such question is how their life cycle relates to their transmissibility and hence nature of being an amyloid or prion, as well

would be biologically beneficial as would lower the spread and impact of any associated disease and hence could be the product of a biological drive to favour αsynuclein to form fibrils that have these properties.

Sup35NM behaves in the reverse, with a low stability and high elongation rate. These would allow a large number of small seeds to be produced rapidly, which would facilitate the spread of aggregates between individual yeast cells and speed up their growth once they enter the cell. As a functional prion, these properties are desirable as would allow the rapid activation of their associated phenotype within an individual as well as its neighbours. This again could suggest that as these properties would be favoured they would be selected for.

Item Type: Thesis (Master of Research (MRes))
Thesis advisor: Xue, Wei-Feng
Uncontrolled keywords: Amyloid Prion Sup35NM Alpha-Synuclein
Subjects: Q Science > QR Microbiology
Divisions: Faculties > Sciences > School of Biosciences
SWORD Depositor: System Moodle
Depositing User: System Moodle
Date Deposited: 10 Jan 2020 12:10 UTC
Last Modified: 13 Jan 2020 10:05 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/79539 (The current URI for this page, for reference purposes)
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