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Preliminary assessment of aneuploidy rates between the polar, mid and mural trophectoderm

Taylor, Tyl H., Stankewicz, Tiffany, Katz, Seth L., Patrick, Jennifer L., Johnson, Lauren, Griffin, Darren K. (2019) Preliminary assessment of aneuploidy rates between the polar, mid and mural trophectoderm. Zygote, . pp. 1-4. ISSN 0967-1994. E-ISSN 1469-8730. (doi:10.1017/S0967199419000637) (KAR id:79520)

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https://doi.org/10.1017/S0967199419000637

Abstract

The objective of this study is to compare aneuploidy rates between three distinct areas of the human trophectoderm: mural, polar and a region in between these two locations termed the ‘mid’ trophectoderm. This is a cohort study on in vitro fertilization (IVF) patients undergoing comprehensive chromosome screening at the blastocyst stage at a private IVF clinic. All embryos underwent assisted hatching on day 3 with blastocyst biopsy and comprehensive chromosome screening. Biopsied blastocysts were divided into three groups depending on which area (polar, mid, or mural) of the trophectoderm was protruding from the zona pellucida and biopsied. Aneuploidy rates were significantly higher with cells from the polar region of the trophectoderm (56.2%) compared with cells removed from the mural region of the trophectoderm (30.0%; P = 0.0243). A comparison of all three areas combined also showed a decreasing trend, but this did not reach clinical significance, polar (56.2%), mid (47.4%) and mural trophectoderm (30.0%; P = 0.1859). The non-concordance demonstrated between polar and mural trophectoderm can be attributed to biological occurrences including chromosomal mosaicism or procedural differences between embryologists.

Item Type: Article
DOI/Identification number: 10.1017/S0967199419000637
Uncontrolled keywords: Aneuploidy, Comprehensive chromosome screening, Embryo biopsy, In vitro fertilizaton (IVF), Preimplantation genetic screening
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Sue Davies
Date Deposited: 09 Jan 2020 09:02 UTC
Last Modified: 09 Jan 2020 09:24 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/79520 (The current URI for this page, for reference purposes)
Griffin, Darren K.: https://orcid.org/0000-0001-7595-3226
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