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Requirements for scribble expression in newly formed gonads of Drosophila embryos

Marhold, J., Papagiannouli, F, Li, M., Patel, A., Mechler, B.M. (2003) Requirements for scribble expression in newly formed gonads of Drosophila embryos. Gene Expression Patterns, 3 (2). pp. 143-146. ISSN 1567-133X. (doi:10.1016/S1567-133X(03)00026-7) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:78996)

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http://dx.doi.org/10.1016/S1567-133X(03)00026-7

Abstract

The tumour suppressor gene scribble (scrib) is required for epithelial polarity and growth control in Drosophila, and encodes two protein isoforms. Here, we report the pattern of Scrib1 synthesis in pole cells and embryonic gonads. We found that Scrib1 synthesis became strongly enhanced in pole cells at the time of gonad formation and was also detectable in cortical domains of gonadal mesodermal cells adjacent to pole cells. Scrib1 synthesis in mesodermal cells was independent of pole cells and occurred in agametic valois and capsul é en embryonic gonads. In contrast, Scrib1 synthesis in pole cells required contact with gonadal mesodermal cells as revealed by the absence of Scrib1 in wunen or tinman-zinc finger homeodomain-1 pseudo-gonads made only of aggregated pole cells.

Item Type: Article
DOI/Identification number: 10.1016/S1567-133X(03)00026-7
Additional information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Gene Expr. Patterns [Field not mapped to EPrints] C2 - 12711540 [Field not mapped to EPrints] AD - Department of Developmental Genetics, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints] M3 - Article [Field not mapped to EPrints]
Uncontrolled keywords: CapsulÃen, Discs-large 1, Dlg, Drosophila melanogaster, Gonad formation, Homeodomain zinc-finger 1, Lethal (2) giant larvae, Neurotactin, Pole cell migration, Scrib1, Scribble, Scribble1, Tinman, Valois, Vasa, Wunen, homeodomain protein, isoprotein, tumor suppressor protein, zinc finger protein, animal tissue, article, cell polarity, controlled study, Drosophila, embryo development, epithelium cell, gonad development, growth regulation, mesoderm, nonhuman, protein expression, protein function, protein synthesis, Animals, DEAD-box RNA Helicases, Drosophila melanogaster, Drosophila Proteins, Gene Expression Profiling, Germ Cells, Gonads, Membrane Proteins, RNA Helicases, Drosophila melanogaster, Melanogaster
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Fani Papagiannouli
Date Deposited: 26 Nov 2019 15:26 UTC
Last Modified: 16 Nov 2021 10:26 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/78996 (The current URI for this page, for reference purposes)

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