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Chapter Five - The HOX-Apoptosis Regulatory Interplay in Development and Disease

Domsch, K. and Papagiannouli, F and Lohmann, I. (2015) Chapter Five - The HOX-Apoptosis Regulatory Interplay in Development and Disease. 114 . pp. 121-158. (doi:10.1016/bs.ctdb.2015.07.014) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:78985)

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Apoptosis is a cellular suicide program, which is on the one hand used to remove superfluous cells thereby promoting tissue or organ morphogenesis. On the other hand, the programmed killing of cells is also critical when potentially harmful cells emerge in a developing or adult organism thereby endangering survival. Due to its critical role apoptosis is tightly controlled, however so far, its regulation on the transcriptional level is less studied and understood. Hox genes, a highly conserved gene family encoding homeodomain transcription factors, have crucial roles in development. One of their prominent functions is to shape animal body plans by eliciting different developmental programs along the anterior-posterior axis. To this end, Hox proteins transcriptionally regulate numerous processes in a coordinated manner, including cell-type specification, differentiation, motility, proliferation as well as apoptosis. In this review, we will focus on how Hox proteins control organismal morphology and function by regulating the apoptotic machinery. We will first focus on well-established paradigms of Hox-apoptosis interactions and summarize how Hox transcription factors control morphological outputs and differentially shape tissues along the anterior-posterior axis by fine-tuning apoptosis in a healthy organism. We will then discuss the consequences when this interaction is disturbed and will conclude with some ideas and concepts emerging from these studies. © 2015 Elsevier Inc.

Item Type: Review
DOI/Identification number: 10.1016/bs.ctdb.2015.07.014
Additional information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Curr. Top. Dev. Biol. [Field not mapped to EPrints] C2 - 26431566 [Field not mapped to EPrints] AD - Centre for Organismal Studies (COS) Heidelberg, Heidelberg University, Heidelberg, Germany [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints] M3 - Book Chapter [Field not mapped to EPrints] C3 - Current Topics in Developmental Biology [Field not mapped to EPrints]
Uncontrolled keywords: Apoptosis, Cancer, Hox genes, Morphogenesis, Morphogenesis, PCD, Programmed cell death, homeodomain protein, transcription factor, animal, apoptosis, gene expression regulation, genetics, homeobox, human, leukemia, metabolism, neoplasm, pathology, physiology, Animals, Apoptosis, Gene Expression Regulation, Gene Expression Regulation, Developmental, Gene Expression Regulation, Leukemic, Gene Expression Regulation, Neoplastic, Genes, Homeobox, Homeodomain Proteins, Humans, Leukemia, Neoplasms, Transcription Factors
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Fani Papagiannouli
Date Deposited: 26 Nov 2019 15:53 UTC
Last Modified: 17 Aug 2022 11:02 UTC
Resource URI: (The current URI for this page, for reference purposes)

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