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The deposition and clearance of liposome entrapped 99mTc-DTPA in the human respiratory tract

Barker, S.A., Taylor, K.M.G., Short, M.D. (1994) The deposition and clearance of liposome entrapped 99mTc-DTPA in the human respiratory tract. International Journal of Pharmaceutics, 102 (1-3). pp. 159-165. ISSN 0378-5173. (doi:10.1016/0378-5173(94)90051-5) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:78875)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
https://doi.org/10.1016/0378-5173(94)90051-5

Abstract

The size characteristics of aerosols produced by nebulising liposomes from five jet nebulisers have been investigated. The size and size distribution of the aerosols was determined by the design of the nebuliser and the gas flow rate employed to drive the nebuliser, rather than on the properties of the liposome preparations themselves. The clearance of inhaled dipalmitoylphosphatidylcholine/cholesterol liposomes containing the aqueous phase marker 99mTc-DTPA was studied by gamma-scintigraphy following inhalation by three healthy volunteers. Approx. 45% of originally deposited radioactivity remained in the lungs after 24 h. This represents the fraction of the radiolabel remaining in intact alveolar-deposited vesicles, since free 99mTc-DTPA was removed from the airways with a half-life of 75 min.

Item Type: Article
DOI/Identification number: 10.1016/0378-5173(94)90051-5
Uncontrolled keywords: 99mTc, Aerosol, Drug delivery system, Gamma scintigraphy, Liposome, Nebuliser, Pulmonary clearance, Pulmonary deposition, liposome, pentetate technetium tc 99m, adult, aerosol, article, drug delivery system, drug formulation, human, human experiment, isotope labeling, male, nebulizer, normal human, particle size, priority journal, respiratory system, scintigraphy, volunteer
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Susan Barker
Date Deposited: 27 Nov 2019 15:04 UTC
Last Modified: 27 Nov 2019 15:04 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/78875 (The current URI for this page, for reference purposes)
Barker, S.A.: https://orcid.org/0000-0003-4880-0253
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