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An investigation into the mechanisms of self-emulsification using particle size analysis and low frequency dielectric spectroscopy

Craig, D.Q.M., Barker, S.A., Banning, D., Booth, S.W. (1995) An investigation into the mechanisms of self-emulsification using particle size analysis and low frequency dielectric spectroscopy. International Journal of Pharmaceutics, 114 (1). pp. 103-110. ISSN 0378-5173. (doi:10.1016/0378-5173(94)00222-Q) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:78874)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
https://doi.org/10.1016/0378-5173(94)00222-Q

Abstract

A series of mixtures comprising Imwitor 742 and Tween 80 have been prepared and their self-emulsifying properties studied using a method of visual examination. The particle size distributions of emulsions prepared from these mixtures at 25°C, 37°C in water and 37°C in 0.1 M HCl have been measured. A marked decrease in mean particle size was observed for 30 and 40% Imwitor 742/Tween 80 mixtures at 25°C with a decrease in particle size also being noted for the majority of Imwitor 742/Tween 80 compositions at higher temperatures. Low frequency dielectric spectroscopy was performed on the pure components and on binary systems to which water had been added to make 50% v/v mixtures. Evidence was shown for the formation of liquid crystalline phases at concentrations corresponding to those shown to be efficient self-emulsifying systems. The study therefore suggests that self-emulsification may be associated with liquid crystal formation and that low frequency dielectric spectroscopy may be of considerable use in understanding the factors leading to self-emulsification.

Item Type: Article
DOI/Identification number: 10.1016/0378-5173(94)00222-Q
Uncontrolled keywords: Dielectric, Emulsion, Glyceride, Imwitor, Particle size, Self-emulsifying system, Tween, emulsifying agent, imwitor 742, polysorbate 80, unclassified drug, article, dielectric constant, drug dosage form, drug mixture, emulsion, particle size, physical chemistry, priority journal, solubilization, spectroscopy, temperature
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Susan Barker
Date Deposited: 27 Nov 2019 13:50 UTC
Last Modified: 27 Nov 2019 13:50 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/78874 (The current URI for this page, for reference purposes)
Barker, S.A.: https://orcid.org/0000-0003-4880-0253
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